Beyond Patient Reported Pain: Perfusion Magnetic Resonance Imaging Demonstrates Reproducible Cerebral Representation of Ongoing Post-Surgical Pain

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A spectropolarimetric view on the nature of the peculiar Type I SN 2005hk

We report two spectropolarimetric observations of SN 2005hk, which is a close copy of the "very peculiar" SN 2002cx, showing low peak luminosity, slow decline, high ionization near peak and an unusually low expansion velocity of only about 7,000 km s^-1. Further to the data presented by Chornock et al., (2006), at -4 days before maximum, we present data of this object taken on 9 November 2005 (near maximum) and 23 November (+ two weeks) that show the continuum and most of the spectral lines to be polarized at levels of about 0.2-0.3%. At both epochs the data corresponds to the Spectropolarimetric Type D1. The general low level of line polarization suggests that the line forming regions for most species observed in the spectrum have a similar shape to that of the photosphere, which deviates from a spherical symmetry by <10%. In comparison with spectropolarimetry of Type Ia and Core-collapse SNe at similar epochs, we find that the properties of SN 2005hk are most similar to those of Type Ia SNe. In particular, we find the low levels of continuum and line polarization to indicate that the explosion mechanism is approximately spherical, with homogeneous ejecta (unlike the chemically segregated ejecta of CCSNe). We discuss the possibility that SN 2005hk was the result of the pure deflagration of a white dwarf and note the issues concerning this interpretation.Comment: ApJ accepted, uses emulateapj, 16 pages, 10 figures, figures 3 and 4 update

Spectropolarimetry of the Type Ia SN 2007sr Two Months After Maximum Light

We present late time spectropolarimetric observations of SN 2007sr, obtained with the VLT telescope at ESO Paranal Observatory when the object was 63 days after maximum light. The late time spectrum displays strong line polarization in the CaII absorption features. SN 2007sr adds to the case of some normal Type Ia SNe that show high line polarization or repolarization at late times, a fact that might be connected with the presence of high velocity features at early times

Properties of extragalactic dust inferred from linear polarimetry of Type Ia Supernovae

Aims: The aim of this paper is twofold: 1) to investigate the properties of extragalactic dust and compare them to what is seen in the Galaxy; 2) to address in an independent way the problem of the anomalous extinction curves reported for reddened Type Ia Supernovae (SN) in connection to the environments in which they explode. Methods: The properties of the dust are derived from the wavelength dependence of the continuum polarization observed in four reddened Type Ia SN: 1986G, 2006X, 2008fp, and 2014J. [...] Results: All four objects are characterized by exceptionally low total-to-selective absorption ratios (R_V) and display an anomalous interstellar polarization law, characterized by very blue polarization peaks. In all cases the polarization position angle is well aligned with the local spiral structure. While SN~1986G is compatible with the most extreme cases of interstellar polarization known in the Galaxy, SN2006X, 2008fp, and 2014J show unprecedented behaviours. The observed deviations do not appear to be connected to selection effects related to the relatively large amounts of reddening characterizing the objects in the sample. Conclusions: The dust responsible for the polarization of these four SN is most likely of interstellar nature. The polarization properties can be interpreted in terms of a significantly enhanced abundance of small grains. The anomalous behaviour is apparently associated with the properties of the galactic environment in which the SN explode, rather than with the progenitor system from which they originate. For the extreme case of SN2014J, we cannot exclude the contribution of light scattered by local material; however, the observed polarization properties require an ad hoc geometrical dust distribution.Comment: 10 pages, 6 figures, accepted for publication in Astronomy and Astrophysic

Method for classifying images in databases through deep convolutional networks

Since 2006, deep structured learning, or more commonly called deep learning or hierarchical learning, has become a new area of research in machine learning. In recent years, techniques developed from deep learning research have impacted on a wide range of information and particularly image processing studies, within traditional and new fields, including key aspects of machine learning and artificial intelligence. This paper proposes an alternative scheme for training data management in CNNs, consisting of selective-adaptive data sampling. By means of experiments with the CIFAR10 database for image classification

Neural correlates of visuospatial working memory in the ‘at-risk mental state’

Background. Impaired spatial working memory (SWM) is a robust feature of schizophrenia and has been linked to the risk of developing psychosis in people with an at-risk mental state (ARMS). We used functional magnetic resonance imaging (fMRI) to examine the neural substrate of SWM in the ARMS and in patients who had just developed schizophrenia. Method. fMRI was used to study 17 patients with an ARMS, 10 patients with a first episode of psychosis and 15 agematched healthy comparison subjects. The blood oxygen level-dependent (BOLD) response was measured while subjects performed an object–location paired-associate memory task, with experimental manipulation of mnemonic load. Results. In all groups, increasing mnemonic load was associated with activation in the medial frontal and medial posterior parietal cortex. Significant between-group differences in activation were evident in a cluster spanning the medial frontal cortex and right precuneus, with the ARMS groups showing less activation than controls but greater activation than first-episode psychosis (FEP) patients. These group differences were more evident at the most demanding levels of the task than at the easy level. In all groups, task performance improved with repetition of the conditions. However, there was a significant group difference in the response of the right precuneus across repeated trials, with an attenuation of activation in controls but increased activation in FEP and little change in the ARMS. Conclusions. Abnormal neural activity in the medial frontal cortex and posterior parietal cortex during an SWM task may be a neural correlate of increased vulnerability to psychosis

“Less is more”: A dose-response account of intranasal oxytocin pharmacodynamics in the human brain

Intranasal oxytocin is attracting attention as a potential treatment for several brain disorders due to promising preclinical results. However, translating findings to humans has been hampered by remaining uncertainties about its pharmacodynamics and the methods used to probe its effects in the human brain. Using a dose-response design (9, 18 and 36 IU), we demonstrate that intranasal oxytocin-induced changes in local regional cerebral blood flow (rCBF) in the amygdala at rest, and in the covariance between rCBF in the amygdala and other key hubs of the brain oxytocin system, follow a dose-response curve with maximal effects for lower doses. Yet, the effects on local rCBF might vary by amygdala subdivision, highlighting the need to qualify dose-response curves within subregion. We further link physiological changes with the density of the oxytocin receptor gene mRNA across brain regions, strengthening our confidence in intranasal oxytocin as a valid approach to engage central targets. Finally, we demonstrate that intranasal oxytocin does not disrupt cerebrovascular reactivity, which corroborates the validity of haemodynamic neuroimaging to probe the effects of intranasal oxytocin in the human brain. Data availability: Participants did not consent for open sharing of the data. Therefore, data can only be accessed from the corresponding author upon reasonable reques

A Descriptive Profile of Abused Female Sex Workers in India

This descriptive study presents the profiles of abused female sex workers (FSWs) in Chennai, India. Of 100 abused FSWs surveyed using a structured questionnaire, severe forms of violence by intimate partners were reported by most (98%) respondents. Of the total sample, 76% experienced violence by clients. Sexual coercion experiences of the FSWs included verbal threats (77%) and physical force (87%) by intimate partners and forced unwanted sexual acts (73%) by clients. While 39% of the women consumed alcohol before meeting a client, 26% reported that their drunkenness was a trigger for violence by clients. The findings suggest that there is an urgent need to integrate services, along with public-health interventions among FSWs to protect them from violence. Recognition of multiple identities of women in the contexts of intimate relationships versus sex work is vital in helping women to stay safe from adverse effects on health

Continuum Foreground Polarization and Na i Absorption in Type Ia SNe

We present a study of the continuum polarization over the 400-600 nm range of 19 SNe Ia obtained with FORS at the VLT. We separate them into those that show Na i D lines at the velocity of their hosts and those that do not. Continuum polarization of the sodium sample near maximum light displays a broad range of values, from extremely polarized cases like SN 2006X to almost unpolarized ones like SN 2011ae. The non-sodium sample shows, typically, smaller polarization values. The continuum polarization of the sodium sample in the 400-600 nm range is linear with wavelength and can be characterized by the mean polarization (Pmean). Its values span a wide range and show a linear correlation with color, color excess, and extinction in the visual band. Larger dispersion correlations were found with the equivalent width of the Na i D and Ca ii H and K lines, and also a noisy relation between Pmean and RV, the ratio of total to selective extinction. Redder SNe show stronger continuum polarization, with larger color excesses and extinctions. We also confirm that high continuum polarization is associated with small values of RV. The correlation between extinction and polarization - and polarization angles - suggest that the dominant fraction of dust polarization is imprinted in interstellar regions of the host galaxies. We show that Na i D lines from foreground matter in the SN host are usually associated with non-galactic ISM, challenging the typical assumptions in foreground interstellar polarization models